CD3 epsilon&CD3 gamma Heterodimer Recombinant Protein
Product Specifications
Background
T-cell surface glycoprotein CD3 delta & CD3 gamma chain, also known as CD3D & CD3G or CD3D&CD3G respectively, are single-pass type I membrane proteins. CD3D, together with CD3- epsilon (CD3E), CD3-gamma and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.
CAS Number
9000-83-3
NCBI Gene ID
916
Swiss Prot
P07766
Accession Number
NP_000724.1 (CD3E) & AAI13831.1 (CD3G)
Tag
His Tag & Fc Tag & Flag Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
39.2 kDa (CD3E) & 38.6 kDa (CD3G)
Applications Notes
Human CD3E&CD3G Heterodimer Protein, Fc, His Tag&Fc, Flag Tag is produced by co-expression of CD3E and CD3G, has a calculated MW of 39.2 kDa (CD3E) and 38.6 kDa (CD3G) . Subunit CD3E is fused with a human IgG1 Fc tag at the C-terminus, followed by a polyhist
NCBI Official Name
CD3e molecule
NCBI Organism
Homo sapiens
Background Reference 01
Gold DP, et al., 1986, Nature 321 (6068) : 431–4.
Background Reference 02
Clevers HC, et al., 1988, Proc. Natl. Acad. Sci. U.S.A. 85 (21) : 8156–60.
Background Reference 03
Gil J, et al., 2011, J Clin Invest, 121 (10) :3872-6.
Background Reference 04
Lu X, et al.,2011, Hematology, 16 (3) :185-9.
Other Product Names
CD3 epsilon & CD3 gamma, CD3E & CD3G
Tested Applications
ELISA, WB
Species
Human
Physical Properties
Lyophilized
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