CD273 [PD-L2] Recombinant Protein
Product Specifications
Background
T cells require a signal induced by the engagement of the T cell receptor and a costimulatory signal (s) through distinct T cell surface molecules for optimal T cell activation and tolerance. CD273 (PD-L2) is one of two ligands for programmed death-1 (PD-1; CD279), a member of the CD28 family of immunoreceptors. The other identified ligand is PD-L1. CD273 is broadly expressed and also up regulated in a variety of tumor cell lines. On previously activated T cells, CD273 interaction with PD-1 inhibits TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. CD273 has a costimulatory function on resting T cells activated with suboptimal TCR signals.
CAS Number
9000-83-3
NCBI Gene ID
58205
Swiss Prot
P05112
Accession Number
NP_067371
Tag
Fc Tag
Type
Recombinant Proteins
Source
CHO cells
Field of Research
Immunology, Innate Immunity
Buffer
Lyophilized from 0.2um-filtered solution in PBS. Reconstitute at 100 μ g/ml in sterile PBS.
Shipping Conditions
Room Temp
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C. Working aliquots are stable for up to 3 months when stored at -20˚ C.
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
Programmed cell death 1 ligand 2
NCBI Organism
Mus musculus
Other Product Names
Programmed Cell Death 1 Ligand 2, PDCD1 Ligand 2, B7-CD, PDL2
Species
Mouse
Protein ID
10946740
Physical Properties
Lyophilized
Frequently Asked Questions
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