Syntenin-1 Recombinant Protein

Product Specifications

Background

Syntenin-1 is a molecule linking syndecan-mediated signaling to the cytoskeleton. Syntenin-1 is primarily localized to membrane-associated adherens junctions and focal adhesions but also found at the endoplasmic reticulum and nucleus. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. Syntenin-1 may affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. It seems to function as an adapter protein, in adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Syntenin-1 seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) and play a role in vesicular trafficking.

CAS Number

9000-83-3

NCBI Gene ID

6386

Swiss Prot

O00560

Accession Number

O00560

Tag

C-6 His tag

Type

Recombinant Proteins

Source

E. coli

Field of Research

Cancer

Buffer

Supplied as a 0.2 um filtered solution of 20mM PB,150mM NaCl, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml.

Shipping Conditions

Dry Ice

Calculated Molecular Weight

33.5 kD

Applications Notes

This recombinant protein can be used for biological assays. For research use only.

NCBI Official Name

Syndecan binding protein

NCBI Organism

Homo sapiens

Other Product Names

Syntenin-1, Melanoma differentiation-associated protein 9, Pro-TGF-alpha cytoplasmic domain-interacting protein 18, Scaffold protein Pbp1, Syndecan-binding protein 1, SDCBP, MDA9, SYCL