SIRP beta / CD172b Recombinant Protein
Product Specifications
Background
Signal-regulatory protein beta-1 (SIRP beta 1) also known as SIRPβ1, belongs to signal-regulatory-protein (SIRP) family, and immunoglobulin superfamily. SIRPβ1 is a transmembrane protein that has three Ig-like domains in its extracellular region and a short cytoplasmic tail. Human SIRPβ1 is expressed on monocytes and granulocytes but not on lymphocytes. SIRP beta 1 contains short cytoplasmic domains that lack cytoplasmic sequence motifs capable of recruiting SHP-2 and SHP-1. In addition, they contain a single basic lysine residue within the hydrophobic transmembrane domain.
NCBI Gene ID
10326
Swiss Prot
Q5TFQ8
Accession Number
NP_006056.2
Tag
Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Signal Transduction
Purity
>90% as determined by SDS-PAGE.
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=11-452
Calculated Molecular Weight
63.7 kDa
Applications Notes
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 63.7 kDa. The protein migrates as 70-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
Signal regulatory protein beta 1
NCBI Organism
Homo sapiens
Background Reference 01
Gaikwad S., et al. 2009, Am J Pathol., 175 (6), 2528-39.
Background Reference 02
Dietrich J., et al. 2000, J Immunol., 164 (1), 9-12.
Background Reference 03
Tomasello E., et al. 2000, Eur J Immunol., 30 (8), 2147-56.
Other Product Names
CD172b antigen, CD172b, DKFZp686A05192, FLJ26614, SIRP beta 1, SIRPB1, SIRP-BETA-1,9930027N05Rik, SIRP-beta
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
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