SERPIND1 Recombinant Protein
Product Specifications
Background
Serpin D1 is also known as Heparin cofactor 2 (HCF2), Protease inhibitor leuserpin-2 (HLS2), Heparin cofactor II (HC-II), which belongs to the serpin family. HCF2 is expressed predominantly in liver. Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, SerpinD1 / HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III) . In a glycosaminoglycan-independent manner, serpinD1 / HC-II also inhibits chymotrypsin. Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.
CAS Number
9000-83-3
NCBI Gene ID
3053
Swiss Prot
P05546
Accession Number
AAH35028
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>95% as determined by SDS-PAGE.
Buffer
50 mM Tris, 150 mM NaCl, pH 7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
55.7 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Serpin peptidase inhibitor, clade D (heparin cofactor), member 1
NCBI Organism
Homo sapiens
Background Reference 01
Van Deerlin V.M.D., et al., 1991, J. Biol. Chem. 266:20223-20231.
Other Product Names
SerpinD1, HCF2, HLS2, HC-II
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
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