SPINK1 Recombinant Protein
Product Specifications
Background
Serine Protease Inhibitor Kazal-Type 1 (SPINK1) is a trypsin inhibitor that prevent the trypsin-catalyzed premature activation of zymogens within the pancreas. Defects in SPINK1 are a cause of pancreatitis (PCTT) . A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks. Defects in SPINK1 are the cause of susceptibility to tropical calcific pancreatitis (TCP) . Recombinant SPINK1 protein (rSPINK1) stimulated cell proliferation in benign RWPE as well as cancerous prostate cells. The research result indicated that the potential of SPINK1 as an extracellular therapeutic target in prostate cancer. In contrast, knockdown of SPINK1 in 22RV1 cells inhibited cell proliferation, cell invasion, and tumor growth in xenograft assays.
NCBI Gene ID
6690
Swiss Prot
P00995
Accession Number
P00995
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Other
Buffer
Supplied as a 0.2 um filtered solution of 20mM MES, 150mM NaCl, 2mM CaCl2, 1mM DTT, 0.05% Brij35, 10% Glycerol, pH 6.0. It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Shipping Conditions
Dry Ice
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=91-492
Calculated Molecular Weight
7.28 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Serine peptidase inhibitor, Kazal type 1
NCBI Organism
Homo sapiens
Other Product Names
Pancreatic Secretory Trypsin Inhibitor, Serine Protease Inhibitor Kazal-Type 1, Tumor-Associated Trypsin Inhibitor, TATI, SPINK1, PSTI
Species
Human
Protein ID
530427178
Physical Properties
Liquid
CAS Number
9000-83-3
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