SLAMF1 / SLAM / CD150 Recombinant Protein
Product Specifications
Background
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family, also known as CD150, is the prototypic member of the SLAM subfamily of the CD2 protein family.SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. The type I transmembrane glycoprotein Signaling Lymphocytic Activation Molecule (SLAM) .
NCBI Gene ID
6504
Swiss Prot
Q13291
Accession Number
NP_003028.1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=11-493
Calculated Molecular Weight
26.2 kDa
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.2 kDa. The protein migrates as 42-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
Signaling lymphocytic activation molecule family member 1
NCBI Organism
Homo sapiens
Background Reference 01
Cannons JLt, et al., 2011, Annu Rev Immunol., 29, 665-705.
Background Reference 02
Jordan MA, et al., 2011, J Immunol., 186 (7), 3953-65.
Background Reference 03
Berger SB, et al., 2010, Nat Immunol., 11 (10), 920-7.
Other Product Names
SLAMF1, CD150, CDw150, SLAM, IPO-3
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
Curated Selection
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