Anti-Mouse IFN gamma Antibody (H22)

Anti-Mouse IFN gamma Antibody (H22) is an anti-mouse IFN gamma IgG antibody inhibitor derived from host Armenian Hamster. Anti-Mouse IFN gamma Antibody (H22) abrogates specific binding of I25II-rIFN-γ to macrophages. Anti-Mouse IFN gamma Antibody (H22) inhibits macrophage-activating factor (MAF) (ID50 = 56 ng) . Anti-Mouse IFN gamma Antibody (H22) inhibits IFN-gamma dependent antiviral activity (ID50 = 2 ng) . Anti-Mouse IFN gamma Antibody (H22) neutralizes IFNγ in mice. Anti-Mouse IFN gamma Antibody (H22) can be used for the researches of inflammation and infection, such as arthritis[1][2][3][4].

Product Specifications

CAS Number

[9007-83-4]

UNSPSC

12352203

Target

IFNAR

Type

Inhibitory Antibodies

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/anti-mouse-ifn-gamma-antibody-h22.html

Purity

95.00

Solubility

H2O

Smiles

[Anti-MouseIFNgammaAntibody(H22)]

Molecular Weight

(150 kDa)

References & Citations

[1]Slaney CY, et al. Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting. Clin Cancer Res. 2017 May 15;23 (10) :2478-2490.|[2]Williams RO, et al. Increased limb involvement in murine collagen-induced arthritis following treatment with anti-interferon-gamma. Clin Exp Immunol. 1993 May;92 (2) :323-7.|[3]uzuki Y, et al. The effect of anti-IFN-gamma antibody on the protective effect of Lyt-2+ immune T cells against toxoplasmosis in mice. J Immunol. 1990 Mar 1;144 (5) :1954-6. |[4]Schreiber RD, et al. Monoclonal antibodies to murine gamma-interferon which differentially modulate macrophage activation and antiviral activity. J Immunol. 1985 Mar;134 (3) :1609-18.