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SARS-CoV-2 (COVID-19) Omicron Variant Spike RBD (His-Avi Tag) Recombinant Protein

Product Specifications

Background

SARS-CoV-2 Omicron variant, a variant of concern (VOC), known as B.1.1.529, was detected in South Africa at the end of November in 2021. However, it rapidly spread all over of the world and now it is the dominant variant in the world, which account for more than 90% of the new cases. Omicron variant spike protein carries around 30 amino acid changes, including mutations, deletions and insertions, in which the receptor binding domain (RBD) protein contains 15 mutations. Enhanced transmission of the Omicron variant was observed globally, which is at least 70 times more contagious than the other variants. The Omicron variant affects the effectiveness of COVID-19 vaccine and is resistant to neutralization (monoclonal antibody treatments) to a large extent.

CAS Number

9000-83-3

NCBI Gene ID

43740578

Swiss Prot

P0DTC1

Accession Number

QHD43416.1

Tag

His-Avi tag at C-terminus

Type

Recombinant Proteins

Source

HEK293 cells

Field of Research

Infectious Disease, COVID-19

Purity

> 95% as determined by Bis-Tris PAGE

Buffer

PBS (pH 7.4) .

Shipping Conditions

Dry Ice

Storage Conditions

Store in working aliquots at -70˚ C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Calculated Molecular Weight

35 kD

Applications Notes

This recombinant protein can be used for WB and ELISA. For research use only.

NCBI Official Name

Surface glycoprotein

NCBI Organism

Severe acute respiratory syndrome coronavirus 2

Background Reference 01

Gowrisankar et al. European Physical Journal Plus, 2022, 137 (1), 100.

Background Reference 02

Zhang et al. PNAS of U.S.A. 2021, 118 (47) :e2109905118.

Background Reference 03

Cameroni et al. Nature 2021.

Background Reference 04

Rossler et al. NEJM 2022.

Background Reference 05

Muik et al. Science 2022

Other Product Names

S protein RBD, Spike glycoprotein Receptor-binding domain, S glycoprotein RBD, Spike protein RBD, Delta variant spike RBD

Tested Applications

ELISA, WB, SDS-PAGE

Species

SARS-CoV-2 (COVID-19, 2019-nCoV) Spike Protein

Physical Properties

Liquid

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