S100B Recombinant Protein
Product Specifications
Background
S-100 protein beta chain (S100B), a member of the S-100 family, is also known as S-100 protein subunit beta and S100 calcium-binding protein B, which contains two EF-hand domains. S100B can weakly bind calcium but bind zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Also, S100B can bind to and initiate the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction, S100B may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Fuethermore, S100B could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. S100B may mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.
NCBI Gene ID
6285
Swiss Prot
P04271
Accession Number
NP_006263
Tag
His Tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Cell Cycle, Neuroscience, Signal Transduction
Purity
>95% as determined by SDS-PAGE.
Buffer
50 mM Tris, 150 mM NaCl, pH8.0
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=96-670
Calculated Molecular Weight
11.5 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
S100 calcium binding protein B
NCBI Organism
Homo sapiens
Background Reference 01
Yamaguchi F., et al., 2012, J. Biol. Chem. 287:13787-13798.
Background Reference 02
Smith S.P., et al., 1998, Structure 6:211-222.
Background Reference 03
McClintock K.A., et al., 2003, J. Biol. Chem. 278:6251-6257.
Other Product Names
S100B, NEF, S100, S100beta
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
Curated Selection
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