Rspondin 1 Recombinant Protein
Product Specifications
Background
R-spondin-1 is also known as Roof plate-specific Spondin 1 (RSPO1) and cysteinerich and single thrombospondin domain containing protein 3 (Cristin 3), which is a secreted protein which belongs to the R-Spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. All Rspondins regulate Wnt/β-catenin signaling, but have distinct expression patterns. Like other R-Spondins, R-Spondin-1 contains two adjacent cysteinerich furinlike domains (aa 34-135) with one potential N-glycosylation site, followed by a thrombospondin (TSP1) motif (aa 147-207) and a region rich in basic residues (aa 211-263) . Only the furinlike domains are needed for β-catenin stabilization. A putative nuclear localization signal at the C-terminus may allow some expression in the nucleus.
CAS Number
9000-83-3
NCBI Gene ID
284654
Swiss Prot
Q2MKA7
Accession Number
NP_001033722.1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Signal Transduction
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=96-658
Calculated Molecular Weight
28.7 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
R-spondin homolog (Xenopus laevis)
NCBI Organism
Homo sapiens
Background Reference 01
Chen, JZ. et al. ,2002, Mol Biol Rep. 2002;29:287.
Background Reference 02
Kim, K.A. et al., 2006, Cell Cycle. 2006;5:23–26.
Background Reference 03
Nam, J.S. et al., 2007, Gene Expr. Patterns 7, 306–312.
Background Reference 04
Kazanskaya, O. et al., 2004, Dev. Cell 7:525.
Other Product Names
RSPO1, CRISTIN3, FLJ40906, RP11-566C13.1, R-spondin-1
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
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