RANK Recombinant Protein

Product Specifications

Background

Receptor Activator of Nuclear Factor κ B (RANK), also known as CD265, TRANCE Receptor or TNFRSF11A, is member of the tumor necrosis factor receptor (TNFR) molecular superfamily. RANK is the receptor for RANK-Ligand (RANKL) and part of the RANK/RANKL/OPG signaling pathway that regulates osteoclast differentiation and activation. It plays a vital role in bone remodeling and repair, immune cell function, lymph node development, thermal regulation, and mammary gland development. RANK is constitutively expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoclast, mammary gland epithelial cells, prostate, vascular cell, and pancreas.

CAS Number

9000-83-3

NCBI Gene ID

8792

Swiss Prot

Q9Y6Q6

Accession Number

Q9Y6Q6

Tag

C-6 His tag

Type

Recombinant Proteins

Source

Human Cells

Field of Research

Chemokines & Cytokines, Immunology, Innate Immunity, Signal Transduction

Buffer

Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

Shipping Conditions

Room Temp

Calculated Molecular Weight

21.1 kD

Applications Notes

This recombinant protein can be used for biological assays. For research use only.

NCBI Official Name

Tumor necrosis factor receptor superfamily member 11a

NCBI Organism

Homo sapiens

Other Product Names

CD265, ODFR, TNFRSF11A, TRANCE R, CD265 antigen, FEO, ODFROSTS, OFE, OPTB7, PDB2, RANK1, Receptor activator of NF-KB, receptor activator of nuclear factor-kappa B, TRANCER, tumor necrosis factor receptor superfamily member 11A