TNFSF11 Recombinant Protein
Product Specifications
Background
Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is known as a type II membrane protein and is a member of the tumor necrosis factor (TNF) superfamily. RANKL, through its ability to stimulate osteoclast formation and activity, is a critical mediator of bone resorption and overall bone density. Some findings also suggestion some cancer cells, particularly prostate cancer cells, can activate an increase in bone remodeling and ultimately increase overall bone production.[17] This increase in bone remodeling and bone production increases the overall growth of bone metastasizes. The overall control of bone remodeling is regulated by the binding of RANKL with its receptor or its decoy receptor, respectively, RANK and OPG.
NCBI Gene ID
8600
Swiss Prot
AAC51762.1
Accession Number
AAC51762.1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=96-959
Calculated Molecular Weight
22.4 kDa
Applications Notes
This recombinant protein can be used for E, WB. For research use only.
NCBI Official Name
TRANCE, partial
NCBI Organism
Homo sapiens
Background Reference 01
Hanada R., et al., 2011, J. Mol. Med. 89 (7) : 647-656.
Background Reference 02
Findlay DM., et al., 2011, Osteoporos Int. 22 (10) : 2597-2602.
Background Reference 03
Schmiedel BJ., et al., 2013, Cancer Res. 73 (2) : 683-694.
Background Reference 04
Castellano D., et al., 2011, Oncologist. 16 (2) : 136-145.
Other Product Names
RANKL, CD254, TRANCE, OPGL, ODF
Tested Applications
ELISA, WB
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
Curated Selection
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