S100A14 Recombinant Protein
Product Specifications
Background
Protein S100-A14 (S100A14) is also known as S100 calcium-binding protein A14 (S114), which belongs to the S-100 family, containing one EF-hand domain.S100A14 is a homodimer can interact with AGER. S100A14 can modulate P53/TP53 protein levels, and play a role in the regulation of cell survival and apoptosis at different concentrations via receptor for advanced glycation end products (RAGE) .S100A14 also plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53.
CAS Number
9000-83-3
NCBI Gene ID
57402
Swiss Prot
Q9HCY8
Accession Number
AAH05019
Tag
His Tag
Type
Recombinant Proteins
Source
E. coli
Purity
>92% as determined by SDS-PAGE.
Buffer
50 mM Tris,150 mM NaCl, pH8.0
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
12.5 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
S100 calcium binding protein A14
NCBI Organism
Homo sapiens
Background Reference 01
Jin Q., et al., 2011, PLoS ONE 6:E19375-E19375.
Background Reference 02
Chen H., et al., 2012, J. Biol. Chem. 287:17109-17119.
Background Reference 03
Sapkota D., et al., 2012, Oral Oncol. 48:219-225.
Other Product Names
S100A14, S114, S100A15
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
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