PSME3 Recombinant Protein
Product Specifications
Background
Proteasome activator complex subunit 3 (PSME3), a member of the PA28 family, is also known as 11S regulator complex subunit gamma (REG-gamma), activator of multicatalytic protease subunit 3 and proteasome activator 28 subunit gamma (PA28gamma) . PSME3 activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. PSME3 can also facilitate the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. Furthermore, PSME3 may also be involved in cell cycle regulation.
NCBI Gene ID
10197
Swiss Prot
P61289
Accession Number
NP_00578
Tag
His Tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Other
Buffer
50 mM Tris, 150 mM NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=96-941
Calculated Molecular Weight
30.3 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Proteasome activator subunit 3
NCBI Organism
Homo sapiens
Background Reference 01
Miki Y., et al., 1994, Science 266:66-71.
Background Reference 02
Realini C., et al., 1997, J. Biol. Chem. 272:25483-25492.
Background Reference 03
Zhang Z., et al., 2008, EMBO J. 27:852-864.
Other Product Names
PSME3, PA28gamma, REG-gamma
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
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