Properdin Recombinant Protein
Product Specifications
Background
Properdin is also known as Complement factor P, CFP, PFC, a positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Properdin is produced by many different leukocyte subsets and circulates as cyclic oligomers of monomeric subunits. Properdin on platelet/granulocyte aggregates (PGA) formation are tightly regulated by Factor H, properdin enhances PGA formation via increased production of C5a, and that inhibition of properdin function has therapeutic potential to limit thromboinflammation in diseases characterized by increased PGA formation.
NCBI Gene ID
18636
Swiss Prot
P11680
Accession Number
NP_032849.2
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=11-238
Calculated Molecular Weight
49.8 kDa
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 49.8 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
Complementfactorproperdin
NCBI Organism
Mus musculus
Background Reference 01
Blatt AZ, et al. 2016. J Immunol. 196 (11) :4671-4680.
Background Reference 02
Pathan S, et al. 2016. Immunol Rev. 274 (1) :172-190.
Other Product Names
Properdin, Complement factor P, CFP, PFC
Tested Applications
WB
Species
Mouse
Physical Properties
Lyophilized
CAS Number
9000-83-3
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