Progranulin Recombinant Protein
Product Specifications
Background
Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD) . In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment) . Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
CAS Number
9000-83-3
NCBI Gene ID
29143
Swiss Prot
P48023
Accession Number
NP_058809
Tag
DDDDK Tag
Type
Recombinant Proteins
Source
HEK293 cells
Buffer
Lyophilized from 0.2um-filtered solution in PBS.
Shipping Conditions
Room Temp
Storage Conditions
Stable for at least 1 year after receipt when stored at -20˚ C.
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
Granulin
NCBI Organism
Rattus norvegicus
Other Product Names
Proepithelin, PEPI, PC Cell-derived Growth Factor
Species
Rat
Protein ID
224967120
Physical Properties
Lyophilized
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