PD-L2 Recombinant Protein
Product Specifications
Background
Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as Butyrophilin B7-DC, CD antigen CD273, which belongs to the immunoglobulin superfamily or BTN/MOG family. The expression of PD-L2 is up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL-4. PD-L2 Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
CAS Number
9000-83-3
NCBI Gene ID
80380
Swiss Prot
Q9BQ51
Accession Number
AAI13679
Tag
Mouse Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=96-938
Calculated Molecular Weight
48.9 kDa
Applications Notes
This recombinant protein can be used for E, WB. For research use only.
NCBI Official Name
Programmed cell death 1 ligand 2
NCBI Organism
Homo sapiens
Background Reference 01
Tseng S.-Y., et al., 2001, J. Exp. Med. 193:839-846.
Background Reference 02
Latchman Y., et al., 2001, Nat. Immunol. 2:261-268.
Background Reference 03
He X.-H., et al., 2004, Acta Biochim. Biophys. Sin. 36:284-289.
Other Product Names
PDL2, PD-L2, Butyrophilin B7-DC, CD273, PDCD1 ligand 2, PDCD1L2, PDCD1LG2
Tested Applications
ELISA, WB
Species
Human
Physical Properties
Lyophilized
Curated Selection
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