CD273 Recombinant Protein
Product Specifications
Background
Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as Butyrophilin B7-DC, CD antigen CD273, which belongs to the immunoglobulin superfamily or BTN/MOG family. The expression of PD-L2 is up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL-4. PD-L2 Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
NCBI Gene ID
80380
Swiss Prot
Q9BQ51
Accession Number
AAI13679
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Apoptosis, Immunology
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH 7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=96-615
Calculated Molecular Weight
23.4 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Programmed cell death 1 ligand 2
NCBI Organism
Homo sapiens
Background Reference 01
Tseng S.-Y., et al., 2001, J. Exp. Med. 193:839-846.
Background Reference 02
Latchman Y., et al., 2001, Nat. Immunol. 2:261-268.
Background Reference 03
He X.-H., et al., 2004, Acta Biochim. Biophys. Sin. 36:284-289.
Other Product Names
PDL2, PD-L2, Butyrophilin B7-DC, CD273, PDCD1 ligand 2, PDCD1L2, PDCD1LG2
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
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