Poly Ig receptor Recombinant Protein
Product Specifications
Background
Polymeric immunoglobulin receptor (PIGR) is also known as Poly-Ig receptor, which can be cleaved into membrane secretory component (SC) . PIGR is a type I transmembrane glycoprotein or a member of the immunoglobulin superfamily, and is synthesized by secretory epithelial cells and delivered to the basolateral plasma membrane where it can bind larger polymers of IgA (pIgA) and pentameric IgM. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
CAS Number
9000-83-3
NCBI Gene ID
5284
Swiss Prot
P01833
Accession Number
AAI10495.1
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology, Other
Purity
>98% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
68.7 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Polymeric immunoglobulin receptor
NCBI Organism
Homo sapiens
Background Reference 01
Krajci P., et al., 1991, Hum. Genet. 87:642-648.
Background Reference 02
Eiffert H., et al., 1984, Hoppe-Seyler's Z. Physiol. Chem. 365:1489-1495.
Background Reference 03
Hughes G.J., et al., 1997, FEBS Lett. 410:443-446.
Background Reference 04
Hamburger A.E., et al., 2004, Structure 12:1925-1935.
Other Product Names
PIGR, Poly-Ig receptor
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
Curated Selection
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