Poliovirus Receptor Recombinant Protein
Product Specifications
Background
Poliovirus Receptor (PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like (Necl) family and was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. PVR contains three Ig-like extracellular domains, a transmembrane segment, and a cytoplasmic tail. The normal cellular function of PVR maybe the involvement of intercellular adhension between epithelial cells. Alternate splicing of the PVR mRNA yields four different isoforms (alpha, beta , gamma , and delta) with identical extracellular domains.
CAS Number
9000-83-3
NCBI Gene ID
5817
Swiss Prot
P15151
Accession Number
P15151
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Infectious Disease, Neuroscience
Buffer
Supplied as a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Shipping Conditions
Dry Ice
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=91-540
Calculated Molecular Weight
36.13 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Poliovirus receptor
NCBI Organism
Homo sapiens
Other Product Names
Poliovirus Receptor, Nectin-Like Protein 5, NECL-5, CD155, PVR, PVS
Species
Human
Protein ID
20149322
Physical Properties
Liquid
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