PDGF R alpha Recombinant Protein

Product Specifications

Background

Platelet-derived growth factor receptors (PDGFR) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. The PDGF family consists of PDGF-A, -B, -C and -D, which form either homo- or heterodimers (PDGF-AA, -AB, -BB, -CC, -DD) . The four PDGFs are inactive in their monomeric forms. PDGFs bind to the protein tyrosine kinase receptors PDGF receptor- alpha and - beta . These two receptor isoforms dimerize upon binding the PDGF dimer, leading to three possible receptor combinations, namely - alpha alpha, - beta beta and - alpha beta . PDGFR alpha and PDGFR beta are members of the class III RTK family. Inappropriate PDGFR alpha and PDGFR beta signaling has been linked to a number of proliferative disorders.

CAS Number

9000-83-3

NCBI Gene ID

18595

Swiss Prot

P26618

Accession Number

P26618

Tag

C-Fc tag

Type

Recombinant Proteins

Source

Human Cells

Field of Research

Cancer, Signal Transduction

Buffer

Lyophilized from a 0.2 um filtered solution of PBS, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

Shipping Conditions

Room Temp

Calculated Molecular Weight

83.2 kD

Applications Notes

This recombinant protein can be used for biological assays. For research use only.

NCBI Official Name

Platelet derived growth factor receptor, alpha polypeptide

NCBI Organism

Mus musculus

Other Product Names

Platelet-derived growth factor receptor alpha, PDGF-R-alpha, PDGFR-alpha, Alpha platelet-derived growth factor receptor, Alpha-type platelet-derived growth factor receptor, CD140 antigen-like family member A, Platelet-derived growth factor alpha receptor, CD140a, PDGFRA