PI4KB Recombinant Protein

Phosphatidylinositol 4-Kinase beta (PI4KB) belongs to the PI3/PI4-kinase family and Type III PI4K subfamily. PI4KB contains one PI3K/PI4K domain and one PIK helical domain. It is highly expressed in heart, skeletal muscle, pancreas, testis and ovary, ; it is lowly expressed in liver tissue. PI4KB kinase activity can be inhibited by wortmannin, and increased by interacting with NCS1/FREQ. PI4KB phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5, -trisphosphate (PIP) . In addition, PI4KB may regulate Golgi disintegration/reorganization during mitosis.

Supplied as a 0.2 um filtered solution of 25mM Tris.HCl, pH7.3,100mM glycine,10%glycerol. It is not recommended to reconstitute to a concentration less than 100 ug/ml.