FKBP12 Recombinant Protein
Product Specifications
Background
Peptidyl-prolyl cis-trans isomerase FKBP1A, a member of the FKBP-type PPIase family and FKBP1 subfamily, is also known as FK506-binding protein 1A, immunophilin FKBP12 and 12 kDa FK506-binding protein, which contains one PPIase FKBP-type domain. FKBP1A is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus) .FKBP1A interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. FKBP1A can also interact with multiple intracellular calcium release channels including the tetrameric skeletal muscle ryanodine receptor. Furthermore, FKBP1A can recruite SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal.
NCBI Gene ID
2280
Swiss Prot
P62942
Accession Number
AAH05147
Tag
His Tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Other
Buffer
50 mM HEPES, 150 mM NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=96-873
Calculated Molecular Weight
12.8 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
FK506 binding protein 1A, 12kDa
NCBI Organism
Homo sapiens
Background Reference 01
Siekierka J.J., et al., 1989, J. Biol. Chem. 265:21011-21015.
Background Reference 02
Michnick S.W., et al., 1990, Science 252:836-839.
Background Reference 03
Van Duyne G.D., et al., 1990, Science 252:839-842.
Other Product Names
FKBP1A, FKBP1, Calstabin-1, FKBP12, Rotamase, PKC12, PPIASE
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
Curated Selection
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