PARP-1 [ARTD1] high purity Recombinant Protein
Product Specifications
Background
PARP-1 (ARTD1) is involved in the base excision repair (BER) pathway, by catalyzing the poly (ADP-ribosyl) ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. PARP-1 positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. It forms a complex with EEF1A1 and TXK that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
CAS Number
9000-83-3
NCBI Gene ID
57097
Swiss Prot
P13501
Accession Number
P09874
Tag
His Tag
Type
Recombinant Proteins
Source
Sf21 cells
Field of Research
Cancer, Innate Immunity, Obesity
Concentration
Lot dependent (0.2-0.5mg/ml)
Purity
>98% (SDS-PAGE)
Buffer
In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride and 50mM imidazole, 0.2% NP-40 and 10% glycerol.
Shipping Conditions
Dry Ice
Storage Conditions
Stable for at least 6 months after receipt when stored at -80˚ C.
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
Poly (ADP-ribose) polymerase family, member 11
NCBI Organism
Homo sapiens
Other Product Names
Poly (ADP-ribose) Polymerase 1, ADP-ribosyltransferase Diphtheria Toxin-like 1, NAD (+) ADP-ribosyltransferase 1
Species
Human
Protein ID
156523968
Physical Properties
Liquid
Curated Selection
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