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PTH1 receptor Recombinant Protein

Product Specifications

Background

Parathyroid hormone 1 receptor (PTH1R) is a multi-pass membrane protein. The protein is expressed in high levels in bone and kidney and regulates calcium ionhomeostasis through activation of adenylate cyclase and phospholipase C. In bone, it is expressed on the surface of osteoblasts. When the receptor is activated through PTH binding, osteoblasts express RANKL (Receptor Activator of Nuclear Factor kB Ligand), which binds to RANK (Receptor Activator of Nuclear Factor kB) on osteoclasts. This turns on osteoclasts to ultimately increase the resorption rate.

CAS Number

9000-83-3

NCBI Gene ID

5745

Swiss Prot

Q0VGD7

Accession Number

Q0VGD7

Tag

C-6 His tag

Type

Recombinant Proteins

Source

Human Cells

Field of Research

Growth Factors, Neuroscience, Signal Transduction, Other

Buffer

Lyophilized from a 0.2 um filtered solution of PBS, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

Shipping Conditions

Room Temp

Calculated Molecular Weight

20.2 kD

Applications Notes

This recombinant protein can be used for biological assays. For research use only.

NCBI Official Name

Parathyroid hormone 1 receptor

NCBI Organism

Homo sapiens

Other Product Names

Parathyroid hormone 1 receptor, PTH1R, PTHR1

Species

Human

Protein ID

767904139

Physical Properties

Lyophilized

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