PTH1 receptor Recombinant Protein
Product Specifications
Background
Parathyroid hormone 1 receptor (PTH1R) is a multi-pass membrane protein. The protein is expressed in high levels in bone and kidney and regulates calcium ionhomeostasis through activation of adenylate cyclase and phospholipase C. In bone, it is expressed on the surface of osteoblasts. When the receptor is activated through PTH binding, osteoblasts express RANKL (Receptor Activator of Nuclear Factor kB Ligand), which binds to RANK (Receptor Activator of Nuclear Factor kB) on osteoclasts. This turns on osteoclasts to ultimately increase the resorption rate.
CAS Number
9000-83-3
NCBI Gene ID
5745
Swiss Prot
Q0VGD7
Accession Number
Q0VGD7
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Growth Factors, Neuroscience, Signal Transduction, Other
Buffer
Lyophilized from a 0.2 um filtered solution of PBS, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
20.2 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Parathyroid hormone 1 receptor
NCBI Organism
Homo sapiens
Other Product Names
Parathyroid hormone 1 receptor, PTH1R, PTHR1
Species
Human
Protein ID
767904139
Physical Properties
Lyophilized
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