HCoV-229E Nucleocapsid Recombinant Protein
Product Specifications
Background
Nucleocapsid (N) protein is the most abundant protein found in coronavirus. CoV N protein is a highly immunogenic phosphoprotein important for viral genome replication and modulation of cell signaling pathways. It was first identified by a research team while they were screening for ADP-ribosylated proteins during coronavirus (CoV) infection (Grunewald M. E., et al. 2017, Virology; 517: 62-68) . The array of diverse functional activities accommodated in N protein makes it more than a structural protein but also an interesting target in the development of antiviral therapeutics. Because of the conservation of N protein sequence and its strong immunogenicity, N protein of coronavirus is chosen as a diagnostic tool.
Tag
His Tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Infectious Disease, COVID-19
Purity
>90% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=11-163
Calculated Molecular Weight
44.4 kDa
Applications Notes
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 44.4 kDa. The protein migrates as 55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background Reference 01
Reuter M, et al. Virus Genes. 2018. 54:5-16.
Background Reference 02
Grunewald ME, et al. Virology. 2018. 517:62-68.
Background Reference 03
Jeeva S, et al. PLoS One. 2017. 12 (9) :e0184935.
Other Product Names
Nucleocapsid protein, NP, Protein N, COVID-19
Tested Applications
WB
Species
HCoV-229E
Physical Properties
Lyophilized
CAS Number
9000-83-3
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