Neutrophil cytosol factor 1 Recombinant Protein
Product Specifications
Background
Neutrophil cytosol factor 1 (NCF1) is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is characterized as a multicomponent enzyme which is activated to produce superoxide anion. NCF2, NCF1, and a membrane bound cytochrome b558 are required for the activation of the latent NADPH oxidase. The human NCF1 gene encodes a 390 amino acids protein without a signal peptide. The NCF1 gene interacts with other subunits of nicotinamide adenine dinucleotide phosphate-oxidase (NADPH) and plays an important role in innate immunity, producing reactive oxygen species and reducing the severity and duration of parasitic infection and autoimmune disease. NCF1 also has a role in T cell activation.
NCBI Gene ID
653361
Swiss Prot
P14598
Accession Number
P14598
Tag
Tag Free
Type
Recombinant Proteins
Source
E. coli
Field of Research
Cancer, Homeostasis, Obesity, Signal Transduction, Other
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM Tris pH8.0,1mM DTT,0.1M NaCl. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=92-514
Calculated Molecular Weight
45.6 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Neutrophil cytosolic factor 1
NCBI Organism
Homo sapiens
Other Product Names
NCF-1/47 kDa autosomal chronic granulomatous disease protein/47 kDa neutrophil oxidase factor/NCF-47K/Neutrophil NADPH oxidase factor 1/Nox organizer 2/Nox-organizing protein 2/SH3 and PX domain-containing protein 1A/p47-phox, NCF1
Species
Human
Protein ID
524552373
Physical Properties
Lyophilized
CAS Number
9000-83-3
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