Neurocalcin-delta Recombinant Protein

Neurocalcin-delta (NCALD) is a neuronal calcium-binding protein that belongs to the neuronal calcium sensor (NCS) family. It expressed in mammalian brains. NCALD contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein possesses a Ca2+ /myristoyl switch. It is cytosolic at resting calcium levels. However, elevated intracellular calcium levels induce a conformational change which exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. NCALD protein is thought to be a regulator of G protein-coupled receptor signal transduction.

Supplied as a 0.2 um filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, 40% Glycerol, pH 8.0. It is not recommended to reconstitute to a concentration less than 100 ug/ml.