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SLAMF 4 Recombinant Protein

Product Specifications

Background

Natural killer cell receptor 2B4 is also known as NK cell type I receptor protein 2B4 (NKR2B4 or h2B4), SLAM family member 4 (SLAMF4), Signaling lymphocytic activation molecule 4, CD antigen CD244. NKR2B4 / CD244 contains two Ig-like (immunoglobulin-like) domains. CD244 is expressed in spleen, PBL, followed by lung, liver, testis and small intestine. CD244 interacts with CD48. Following phosphorylation, CD244 is able to recruit PTPN11/SHP-2 and SH2D1A/SAP. SLAMF4 modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family.

CAS Number

9000-83-3

NCBI Gene ID

51744

Swiss Prot

Q9BZW8

Accession Number

NP_057466

Tag

C-Fc Tag

Type

Recombinant Proteins

Source

HEK293 cells

Field of Research

Immunology, Stem Cell

Purity

>95% as determined by SDS-PAGE.

Buffer

50 mM tris, 100 mM glycine, pH7.5

Shipping Conditions

Room Temp

Storage Conditions

Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

48.9 kDa

Applications Notes

This recombinant protein can be used for WB. For research use only.

NCBI Official Name

CD244 molecule, natural killer cell receptor 2B4

NCBI Organism

Homo sapiens

Background Reference 01

Nakajima H., et al., 1999, Eur. J. Immunol. 29:1676-1683.

Background Reference 02

Kubin M.Z., et al., 1999, Eur. J. Immunol. 29:3466-3477.

Background Reference 03

Boles K.S., et al., 1999, Tissue Antigens 54:27-34.

Other Product Names

CD244, 2B4, SLAMF4, NKR2B4, NAIL, h2B4

Tested Applications

WB

Species

Human

Physical Properties

Lyophilized

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