NCR3 Recombinant Protein
Product Specifications
Background
Natural Cytotoxicity Triggering Receptor 3 (NCR3) along with NKp44 and NKp46 constitute a group of receptors termed “Natural Cytotoxicity Receptors”. They play a major role in triggering NK-mediated killing of most tumor cells lines. NKp30 is a type I transmembrane protein having a single extracellular V-like immunoglobulin domain. NKp30 is selectively expressed both in resting and activated human NK cells. In addition, NKp30 is also involved in NK-mediated induction of dendritic cell (DC) maturation. It has been demonstrated that NK cell activation signaling specifically induces lytic activity against several tumor cell types and synthesis of new NF-κB dependent proteins during the initiation of cytotoxicity.
CAS Number
9000-83-3
NCBI Gene ID
259197
Swiss Prot
O14931
Accession Number
O14931
Tag
C-Fc tag
Type
Recombinant Proteins
Source
Human Cells
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Calculated Molecular Weight
40.2 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Natural cytotoxicity triggering receptor 3
NCBI Organism
Homo sapiens
Other Product Names
Natural Cytotoxicity Triggering Receptor 3, Activating Natural Killer Receptor p30, Natural Killer Cell p30-Related Protein, NK-p30, NKp30, CD337, NCR3, 1C7, LY117
Species
Human
Physical Properties
Lyophilized
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