MINPP1 Recombinant Protein

Multiple Inositol Polyphosphate Phosphatase 1/MINPP1 is an enzyme that removes 3-phosphate from inositol phosphate substrates. MINPP1 also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate. MINPP1 is synthesized as a 487 amino acid precursor that contains an 30 amino acid signal peptide and a 457 amino aicd mature chain. MINPP1 is widely expressed with the highest levels found in kidney, liver and placenta. It acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6) . MINPP1 may play a role in bone development (endochondral ossification) .

Supplied as a 0.2 um filtered solution of 20mM TrisHCl, 150mM NaCl, 10% Glycerol, pH 7.5. It is not recommended to reconstitute to a concentration less than 100 ug/ml.

Multiple Inositol Polyphosphate Phosphatase 1, 2, 3-Bisphosphoglycerate 3-Phosphatase, 3-BPG Phosphatase, Inositol (1, 3, 4, 5) -Tetrakisphosphate 3-Phosphatase, Ins (1, 5) P (4) 3-Phosphatase, MINPP1, MIPP