IL-13 Recombinant Protein
Product Specifications
Background
Mouse interleukin 13 (mIL-13) is a pleiotropic cytokine produced by activated Th2 cells. IL-13 induces B cell proliferation and immunoglobin production. It contains a four helical bundle with two internal disulfide bonds. Mouse IL13 shares 58% sequence identity with human protein and exhibits cross-species activity. IL13 signals via receptor IL13R (type2, IL4R) and activates STAT-6. IL13 initially binds IL-13R alpha1 with low affinity and triggers association of IL4R alpha, generating a high affinity heterodimeric receptor IL13R and eliciting downstream signals. IL13 also binds IL-13R alpha2 with high affinity, which plays a role in a negative feedback system of IL13 signaling. IL13 is an important mediator of allergic inflammation and disease.
NCBI Gene ID
16163
Swiss Prot
P20109
Accession Number
P20109
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Chemokines & Cytokines, Immunology
Buffer
Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=91-928
Calculated Molecular Weight
12.7 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Interleukin 13
NCBI Organism
Mus musculus
Other Product Names
Interleukin-13, IL-13, T-Cell Activation Protein P600, Il13
Species
Mouse
Physical Properties
Lyophilized
CAS Number
9000-83-3
Curated Selection
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