MAPT-D Recombinant Protein
Product Specifications
Background
Microtubule-Associated Protein TAU is abundantly expressed in neurons of the central nervous system and less commonly expressed elsewhere, but is also expressed at very low levels in CNS astrocytes and oligodendrocytes. Tau interacts with tubulin to stabilize microtubules and promotes tubulin assembly into microtubules. The C-terminus of TAU binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau acts as a linker protein. When tau is defective, and no longer stabilize microtubules properly, it can result in dementias such as Alzheimer's disease and other tauopathies.
NCBI Gene ID
4137
Swiss Prot
P10636
Accession Number
P10636
Tag
C-6 His tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Neuroscience, Other
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=91-157
Calculated Molecular Weight
15.37 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Microtubule associated protein tau
NCBI Organism
Homo sapiens
Other Product Names
Microtubule-Associated Protein Tau, Neurofibrillary Tangle Protein, Paired Helical Filament-Tau, PHF-Tau, MAPT, MAPTL, MTBT1, TAU, Tau-D
Species
Human
Physical Properties
Lyophilized
CAS Number
9000-83-3
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