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MICA Recombinant Protein

Product Specifications

Background

MHC class I polypeptide-related sequence A (MICA) belongs to the MHC class I family and MIC subfamily. MICA contains one Ig-like C1-type (immunoglobulin-like) domain. Unlike classical MHC class I molecules, MICA does not form a heterodimer with beta-2-microglobulin. MICA acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. MICA is ligand for the KLRK1/NKG2D receptor. MICA bind to KLRK1 leads to cell lysis.

CAS Number

9000-83-3

NCBI Gene ID

4276

Swiss Prot

Q29983

Accession Number

NP_000238

Tag

His Tag

Type

Recombinant Proteins

Source

HEK293 cells

Field of Research

Immunology

Purity

>95% as determined by SDS-PAGE.

Buffer

PBS, pH7.4

Shipping Conditions

Room Temp

Storage Conditions

Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

33.6 kDa

Applications Notes

This recombinant protein can be used for WB. For research use only.

NCBI Official Name

MHC class I polypeptide-related sequence A

NCBI Organism

Homo sapiens

Background Reference 01

Groh V., et al., 1998, Science 279:1737-1740.

Background Reference 02

Bauer S., et al., 1999, Science 285:727-729.

Background Reference 03

Steinle A., et al., 2001, Immunogenetics 53:279-287.

Other Product Names

MIC-A

Tested Applications

WB

Species

Human

Physical Properties

Lyophilized

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