MICA Recombinant Protein
Product Specifications
Background
MHC class I polypeptide-related sequence A (MICA) belongs to the MHC class I family and MIC subfamily. MICA contains one Ig-like C1-type (immunoglobulin-like) domain. Unlike classical MHC class I molecules, MICA does not form a heterodimer with beta-2-microglobulin. MICA acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. MICA is ligand for the KLRK1/NKG2D receptor. MICA bind to KLRK1 leads to cell lysis.
CAS Number
9000-83-3
NCBI Gene ID
4276
Swiss Prot
Q29983
Accession Number
NP_000238
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
33.6 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
MHC class I polypeptide-related sequence A
NCBI Organism
Homo sapiens
Background Reference 01
Groh V., et al., 1998, Science 279:1737-1740.
Background Reference 02
Bauer S., et al., 1999, Science 285:727-729.
Background Reference 03
Steinle A., et al., 2001, Immunogenetics 53:279-287.
Other Product Names
MIC-A
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
Curated Selection
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