Mesothelin Recombinant Protein
Product Specifications
Background
Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.
CAS Number
9000-83-3
NCBI Gene ID
10232
Swiss Prot
Q13421
Accession Number
AAH09272
Tag
N-Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
59.6 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Mesothelin
NCBI Organism
Homo sapiens
Background Reference 01
Chang K., et al., 1996, Proc. Natl. Acad. Sci. U.S.A. 93:136-140.
Background Reference 02
Yamaguchi N., et al., 1994, J. Biol. Chem. 269:805-808.
Background Reference 03
Rump A., et al., 2004, J. Biol. Chem. 279:9190-9198.
Background Reference 04
Ma J., et al., 2012, J. Biol. Chem. 287:33123-33131.
Other Product Names
MSLN, Mesothelin, MPF
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized
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