Mesothelin / MSLN (296-580) Recombinant Protein
Product Specifications
Background
Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.
CAS Number
9000-83-3
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Cancer
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
33.7 kDa
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 33.7 kDa. The protein migrates as 35-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background Reference 01
Chang K., et al., 1996, Proc. Natl. Acad. Sci. U.S.A. 93:136-140.
Background Reference 02
Yamaguchi N., et al., 1994, J. Biol. Chem. 269:805-808.
Background Reference 03
Rump A., et al., 2004, J. Biol. Chem. 279:9190-9198.
Background Reference 04
Ma J., et al., 2012, J. Biol. Chem. 287:33123-33131.
Other Product Names
MSLN, Mesothelin, MPF
Tested Applications
ELISA, WB
Species
Cynomolgus monkey
Physical Properties
Lyophilized
Curated Selection
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