MMP-1 Recombinant Protein
Product Specifications
Background
Matrix Metalloproteinase-1 (MMP-1) is expressed by fibroblasts, keratinocytes, endothelial cells, monocytes and macrophages. MMP1 contains several distinct domains: a prodomain that is cleaved upon activation, a catalytic domain containing the zinc binding site, a short hinge region, and a carboxyl terminal (hemopexin like) domain. MMP-1 can degrade a broad range of substrates including types I, II, III, VII, VIII, and X collagens as well as casein, gelatin, alpha1 antitrypsin, myelin basic protein, L-Selectin, pro-TNF, IL1, IGFBP3, IGFBP5, pro-MMP2, and pro-MMP9. A significant role of MMP1 is the degradation of fibrillar collagens in extracellular matrix remodeling, characterized by the cleavage of the interstitial collagen triple helix into 3/4, 1/4 fragments. MMP1 may also be involved in enzyme cascades, cytokine regulation and cell surface molecule modulation.
NCBI Gene ID
4312
Swiss Prot
P03956
Accession Number
P03956
Tag
C-6 His tag
Type
Recombinant Proteins
Source
Human Cells
Field of Research
Cancer, Cell Cycle, Homeostasis, Neuroscience, Signal Transduction, Other
Buffer
Supplied as a 0.2 um filtered solution of 20mM MES, 150mM NaCl, 0.05% Brij35, pH 5.5. It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Shipping Conditions
Dry Ice
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=91-344
Calculated Molecular Weight
52.88 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
Matrix metallopeptidase 1
NCBI Organism
Homo sapiens
Other Product Names
Interstitial Collagenase, Fibroblast Collagenase, Matrix Metalloproteinase-1, MMP-1, MMP1, CLG
Species
Human
Physical Properties
Liquid
CAS Number
9000-83-3
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