LIF Recombinant Protein
Product Specifications
Background
LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities also include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation and the stimulation of acute-phase protein synthesis in hepatocytes. LIF activates JAK & STAT signaling in human embryonic stem (ES) cells, but this pathway does not maintain pluripotency in these cells, which instead rely on FGF2-mediated ERK signaling. By contrast, mouse ES cells can be maintained by LIF-mediated JAK & STAT signaling. LIF binds to a high affinity heterodimeric receptor complex consisting of two proteins: LIF-R alpha that binds LIF with low affinity and the 130kDa (gp130) subunit that by itself does not bind LIF, but is required for high affinity binding of LIF.
NCBI Gene ID
3976
Swiss Prot
P13597
Accession Number
P15018
Tag
GST tag
Type
Recombinant Proteins
Source
E. coli
Field of Research
Stem Cell
Concentration
0.1mg/ml after reconstitution
Buffer
Contains PBS. Reconstitute with 100 μ l sterile water.
Shipping Conditions
Room Temp
Storage Conditions
Stable for at least 6 months after receipt when stored at -20˚ C.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=90-277
Applications Notes
This recombinant proteins is for research use only.
NCBI Official Name
Leukemia inhibitory factor
NCBI Organism
Homo sapiens
Other Product Names
Leukemia Inhibitory Factor, Differentiation-stimulating Factor, D Factor, Melanoma-derived LPL Inhibitor
Species
Human, Mouse
Protein ID
4504991
Physical Properties
Lyophilized
CAS Number
9000-83-3
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