CD47 Recombinant Protein
Product Specifications
Background
Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.
CAS Number
9000-83-3
NCBI Gene ID
100355470
Swiss Prot
G1SKT7
Accession Number
G1SKT7
Tag
Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=97-032
Calculated Molecular Weight
40.4 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Leukocyte surface antigen CD47
NCBI Organism
Oryctolagus cuniculus
Background Reference 01
Lindberg F.P., et al., 1993, J. Cell Biol. 123:485-496.
Background Reference 02
Latour S., et al., 2001, J. Immunol. 167:2547-2554.
Background Reference 03
Piccio L., et al., 2005, Blood 105:2421-2427.
Other Product Names
CD47, MER6, IAP, OA3
Tested Applications
WB
Species
Rabbit
Physical Properties
Lyophilized
Curated Selection
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