LILRB4 Recombinant Protein
Product Specifications
Background
Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) is also known as CD85 antigen-like family member K (CD85K), Immunoglobulin-like transcript 3 (ILT-3), Leukocyte immunoglobulin-like receptor 5 (LIR-5), Monocyte inhibitory receptor HM18, which belongs to the leukocyte immunoglobulin-like receptor (LIR) family. LILRB4 / CD85K contains 2 Ig-like C2-type (immunoglobulin-like) domains. CD85K is detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. LILRB4 / CD85K is receptor for class I MHC antigens. CD85K recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles, involved in the down-regulation of the immune response and the development of tolerance. LILRB4 interferes with TNFRSF5-signaling and NF-kappa-B up-regulation and inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
NCBI Gene ID
107128256
Swiss Prot
XP_015297198.1
Accession Number
XP_015297198.1
Tag
Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=96-808
Calculated Molecular Weight
52.7 kDa
Applications Notes
This recombinant protein can be used for E, WB. For research use only.
NCBI Official Name
Leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X1
NCBI Organism
Macaca fascicularis
Background Reference 01
Cella M., et al., 1997, J. Exp. Med. 185:1743-1751.
Background Reference 02
Chang C.C., et al., 2002, Nat. Immunol. 3:237-243.
Other Product Names
LILRB4, ILT3, LIR5, CD85K, HM18
Tested Applications
ELISA, WB
Species
Cynomolgus monkey
Physical Properties
Lyophilized
CAS Number
9000-83-3
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