LILRB4 / CD85k / ILT3 Recombinant Protein
Product Specifications
Background
Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) is also known as CD85 antigen-like family member K (CD85K), Immunoglobulin-like transcript 3 (ILT-3), Leukocyte immunoglobulin-like receptor 5 (LIR-5), Monocyte inhibitory receptor HM18, which belongs to the leukocyte immunoglobulin-like receptor (LIR) family. LILRB4 / CD85K contains 2 Ig-like C2-type (immunoglobulin-like) domains. CD85K is detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. LILRB4 / CD85K is receptor for class I MHC antigens. CD85K recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles, involved in the down-regulation of the immune response and the development of tolerance. LILRB4 interferes with TNFRSF5-signaling and NF-kappa-B up-regulation and inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
NCBI Gene ID
107128256
Accession Number
XP_015297198.1
Tag
Mouse IgG Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Purity
>95% as determined by SDS-PAGE.
Buffer
50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=11-491
Calculated Molecular Weight
53.2 kDa
Applications Notes
This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 53.2 kDa. The protein migrates as 65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
Leukocyte immunoglobulin like receptor B4
NCBI Organism
Macaca fascicularis
Background Reference 01
Cella M., et al., 1997, J. Exp. Med. 185:1743-1751.
Background Reference 02
Chang C.C., et al., 2002, Nat. Immunol. 3:237-243.
Other Product Names
LILRB4, ILT3, LIR5, CD85K, HM18
Tested Applications
WB
Species
Cynomolgus monkey
Physical Properties
Lyophilized
CAS Number
9000-83-3
Curated Selection
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