LRRC32 Recombinant Protein
Product Specifications
Background
Leucine-rich repeat protein 32 (LRRC32), also known as GARP (glycoprotein A repetitions predominant) . LRRC32 expression promotes the acquisition of a Treg phenotype including reduced cellular proliferation, reduced cytokine secretion, and the capacity to suppress the proliferation of naïve T cells. LRRC32 binds directly to the TGF-beta latency associated peptide (LAP) and tethers latent TGF-beta on the surface of activated Treg cells. The presentation of TGF-beta on Tregs contributes to their ability to suppress naïve T cell proliferation.
CAS Number
9000-83-3
NCBI Gene ID
2615
Swiss Prot
Q14392-1
Accession Number
Q14392-1
Tag
Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Field of Research
Immunology
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
92.6 kDa
Applications Notes
This recombinant protein can be used for E, WB. For research use only.
NCBI Official Name
LRRC32 protein
NCBI Organism
Homo sapiens
Background Reference 01
Battaglia, M., et al., 2009, Eur. J. Immunol. 39 (12) : 3296-3300.
Background Reference 02
Wang, R. et al. 2008, PloS ONE 3 (7) : e2705.
Background Reference 03
Probst-Kepper, M. et al. 2009, J. Cell. Mol. Med. 13 (9B) : 3343-3357.
Other Product Names
GARP, Garpin, D11S833E
Tested Applications
ELISA, WB
Species
Human
Physical Properties
Lyophilized
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