Kremen-1 Recombinant Protein
Product Specifications
Background
Kremens are high-affinity receptors for Dickkopf 1 (Dkk1) and regulate the Wnt/β-catenin signaling pathway by down-regulating the low-density lipoprotein receptor-related protein 6 (LRP6) . Kremen1 is considered as one component of a membrane complex modulating canonical Wnt signalling through LRP6 in vertebrates. Additionally, KREMEN1 (KRM1) has also been identified as a functional receptor for Coxsackievirus A10 (CV-A10), a causative agent of hand-foot-and-mouth disease (HFMD) .
CAS Number
9000-83-3
Tag
Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=11-155
Calculated Molecular Weight
67.4 kDa
Applications Notes
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 67.4 kDa. The protein migrates as 80-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Background Reference 01
Mishra SK. et al., PLoS One. 2012;7 (12) : e52190.
Background Reference 02
Bingyu M. et al., Nature, . 2002 Jun 6;417 (6889) :664-7.
Background Reference 03
Yingzi C. et al., PNAS, 2020 117 (31) 18711-18718
Other Product Names
KREMEN, KRM1, Dickkopf receptor/Kringle domain-containing transmembrane protein 1/Kringle-containing protein marking the eye and the nose
Tested Applications
ELISA, WB
Species
Human
Physical Properties
Lyophilized
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