JAM-B Recombinant Protein

Product Specifications

Background

Junctional Adhesion Molecule B (JAM-B) is a single-pass type I membrane protein that belongs to the juctional adhesion molecules family. JAM-B includes a signal sequence (aa 1-28), an extracellular region (aa 29-238) with one Ig-like C2-type domain and one Ig-like V-type domain, a transmembrane segment (aa 239-259), and a cytoplasmic domain (aa 260 - 298) . JAMB is localized to the tight junctions between endothelial cells or epithelial cells. JAM-B is prominently expressed in the heart, placenta, lung, foreskin and lymph node. It is also present on the endothelia of other vessels. JAM-B acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.

CAS Number

9000-83-3

NCBI Gene ID

58494

Swiss Prot

P57087

Accession Number

P57087

Tag

C-Fc tag

Type

Recombinant Proteins

Source

Human Cells

Field of Research

Signal Transduction

Buffer

Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4 . It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.

Shipping Conditions

Room Temp

Calculated Molecular Weight

50.3 kD

Applications Notes

This recombinant protein can be used for biological assays. For research use only.

NCBI Official Name

Junctional adhesion molecule 2

NCBI Organism

Homo sapiens

Other Product Names

Junctional Adhesion Molecule B, JAM-B, Junctional Adhesion Molecule 2, JAM-2, Vascular Endothelial Junction-Associated Molecule, VE-JAM, CD322, JAM2, C21orf43, VEJAM