CD130 Recombinant Protein
Product Specifications
Background
Interleukin-6 receptor subunit beta (IL6ST) is also known as IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, Interleukin-6 signal transducer, Membrane glycoprotein 130 (gp130), CD130, Oncostatin-M receptor subunit alpha and Il6st, which is single-pass type I membrane protein. IL6ST /gp130 /CD130 can be found in tissues such as brain, heart, thymus, spleen, kidney, lung and liver and found in all the cell lines tested except BaF-B03.The expression of IL-6ST /gp130 is not restricted to IL6-responsive cells. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. IL6ST /CD130 can bind to IL6 /IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduce the signal. IL6ST /GP130 does not bind IL6 and may have a role in embryonic development.
NCBI Gene ID
16195
Swiss Prot
Q00560
Accession Number
NP_034690
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>95% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=96-478
Calculated Molecular Weight
68.5 kDa
Applications Notes
This recombinant protein can be used for WB. For research use only.
NCBI Official Name
Interleukin 6 signal transducer
NCBI Organism
Mus musculus
Background Reference 01
Saito M., et al., 1992, J. Immunol. 148:4066-4071. (2) Wollscheid B., et al., 2009, Nat. Biotechnol. 27:378-386. (3) Tanaka M., et al., 1999, Blood 93:804-815.
Background Reference 02
Wollscheid B., et al., 2009, Nat. Biotechnol. 27:378-386.
Background Reference 03
Tanaka M., et al., 1999, Blood 93:804-815.
Other Product Names
IL6ST, gp130, CD130, IL-6RB, IL-6R-beta, CDw130
Tested Applications
WB
Species
Mouse
Physical Properties
Lyophilized
CAS Number
9000-83-3
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