CD130 Recombinant Protein

Product Specifications

Background

Interleukin-6 receptor subunit beta (IL6ST) is also known as IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, Interleukin-6 signal transducer, Membrane glycoprotein 130 (gp130), CD130, Oncostatin-M receptor subunit alpha and Il6st, which is single-pass type I membrane protein. IL6ST /gp130 /CD130 can be found in tissues such as brain, heart, thymus, spleen, kidney, lung and liver and found in all the cell lines tested except BaF-B03.The expression of IL-6ST /gp130 is not restricted to IL6-responsive cells. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. IL6ST /CD130 can bind to IL6 /IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduce the signal. IL6ST /GP130 does not bind IL6 and may have a role in embryonic development.

CAS Number

9000-83-3

NCBI Gene ID

16195

Swiss Prot

Q00560

Accession Number

NP_034690

Tag

His Tag

Type

Recombinant Proteins

Source

HEK293 cells

Purity

>95% as determined by SDS-PAGE.

Buffer

PBS, pH7.4

Shipping Conditions

Room Temp

Storage Conditions

Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

68.5 kDa

Applications Notes

This recombinant protein can be used for WB. For research use only.

NCBI Official Name

Interleukin 6 signal transducer

NCBI Organism

Mus musculus

Background Reference 01

Saito M., et al., 1992, J. Immunol. 148:4066-4071. (2) Wollscheid B., et al., 2009, Nat. Biotechnol. 27:378-386. (3) Tanaka M., et al., 1999, Blood 93:804-815.