IL-36 gamma Recombinant Protein
Product Specifications
Background
Interleukin-36 gamma (IL-36 gamma) is a member of the interleukin 1 cytokine family that includes three closely related genes, IL-36 alpha, beta , and gamma , formerly known as IL-1F6, F8, and F9 respectively. IL-36 alpha has been detected in both neuronal and synovial tissue, whereas IL-36 beta and IL-36 gamma are expressed in both cutaneous and mucosal epithelial cells, including the respiratory tract. IL-36 beta and IL-36 gamma stimulate proliferation, maturation and/or cytokine expression by innate immune cells (such as keratinocytes and dendritic cells), and adaptive immune cells (neutrophils and T-cells) in both humans and mice. The activity of IL-36 alpha is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta) . IL-36 gamma plays an important role in communicating the cell death to surrounding cells.
NCBI Gene ID
6347
Swiss Prot
P13500
Accession Number
P13500
Tag
Tag Free
Type
Recombinant Proteins
Source
E. coli
Field of Research
Chemokines & Cytokines, Immunology, Innate Immunity
Buffer
Lyophilized from a 0.2 um filtered solution of 20mM Tris,100mM Nacl,0.1mM EDTA, pH8.0. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
Shipping Conditions
Room Temp
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=92-669
Calculated Molecular Weight
17 kD
Applications Notes
This recombinant protein can be used for biological assays. For research use only.
NCBI Official Name
C-C motif chemokine ligand 2
NCBI Organism
Homo sapiens
Other Product Names
Interleukin-36 gamma, IL36G, IL-1-related protein 2, IL-1RP2, IL-1 epsilon, IL-1F9, Interleukin-1 homolog 1, IL-1H1
Species
Human
Protein ID
189054143
Physical Properties
Lyophilized
CAS Number
9000-83-3
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